Scientific Premise, Rigor, and Reproducibility are still causing confusion

Are you working on an R01 proposal for the upcoming February 5th NIH deadline?  Like many Principal Investigators, you may have spent a lot of time crafting the perfect write-up of your scientific premise.  Unfortunately, that means you missed the recent notice (NOT-OD-18-228) regarding the changes to NIH grant application instructions that take effect this month.  The references to "scientific premise" have been replaced by an explanation of requirements to address scientific rigor and reproducibility.  Still confused?  See this handy website for guidance on rigor and reproducibility from NIH.