What does it mean when your NIH grant application is "Not Discussed"?

Although it is a few years old, this helpful article from NIAID provides an overview of the proposal review process that explains what it means for a proposal to be classified as Not Discussed.  This designation is also referred to by some of the old-school folks as "unscored" or "bottom-halved".  Interestingly, the article advises that, in some circumstances, it is a good idea to resubmit a Not Discussed proposal.  This is contrary to a common notion that proposals that are not scored should be significantly revamped and submitted as new.  As the article advises, it is important to contact the appropriate staff member from the relevant Institute/Center to discuss the application and your next steps.