Who do I talk to?

Often, individuals refer to the "NIH Program Officer" when speaking of NIH staff members who provide feedback and guidance on planned proposal submissions.  Most RFAs list several points of contact, all with different titles.  How do you know who to contact when you have a question?  Who can review your specific aims to help determine if your project is a good fit for a particular institute or funding opportunity?  A breakdown of the roles of various types of NIH program staff is provided here.  Of particular note, the Program Official "is responsible for the programmatic, scientific, and/or technical aspects of assigned applications and grants".